Nicergolinum [Inn-Latin]: Full Drug Profile

Nicergolinum [Inn-Latin] - General Information

An ergot derivative that has been used as a cerebral vasodilator and in peripheral vascular disease. It has been suggested to ameliorate cognitive deficits in cerebrovascular disease. [PubChem]

Pharmacology of Nicergolinum [Inn-Latin]

Nicergolinum [Inn-Latin] is a potent vasodilator (improves brain blood flow). On the cerebral level it prompts a lowering of vascular resistance, an increase in arterial flow and stimulates the use of oxygen and glucose. Nicergolinum [Inn-Latin] also improves blood circulation in the lungs and limbs and has been shown to inhibit blood platelet aggregation.

Additional information about Nicergolinum [Inn-Latin]

Nicergolinum [Inn-Latin] Indication

For the treatment of senile dementia, migraines of vascular origin, transient ischemia, platelet hyper-aggregability, and macular degeneration.

Mechanism Of Action

Nicergolinum [Inn-Latin] acts by inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. This inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation. Therefore the mechanism of Nicergolinum [Inn-Latin] is to increase vascular circulation in the brain, thereby enhancing the transmission of nerve signals across the nerve fibres, which secrete acetylcholine as a neural transmitter.

Generic Name

Nicergoline

Drug Category

Nootropic Agents; Vasodilator Agents

Drug Type

Small Molecule; Approved

Other Brand Names containing Nicergoline

MNE; Nargoline; Nicergolin [German]; Nicergolina [Dcit]; Nicergoline [Usan-Ban-Inn-Jan]; Nicergolinum [Inn-Latin]; Nicotergoline; Nimergoline; Nimergoline Base; Sermion; Vasospan;

Chemical Formula

C24H26BrN3O3

Nicergoline on Wikipedia

https://en.wikipedia.org/wiki/Nicergoline

Organisms Affected

Humans and other mammals